USA TODAY Sports' Week 4 National Football League picks: Big games in Pittsburgh, Minnesota

JACKSONVILLE FL- AUGUST 28 Head coach Gus Bradley of the Jacksonville Jaguars claps during the second half of the preseason game against the Cincinnati Bengals at Ever Bank Field

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The Indianapolis Colts and Jacksonville Jaguars have faced each other 30 times in history.

COLTS QB Andrew Luck directed a productive 410-yard offense in the win over the Chargers, throwing 24-37-331-1-1 (91.2 QB rating).

Bradley is 12-39 since being hired as the Jaguars' coach in 2013, but in what is shaping up as a muddy AFC South, it's not impossible to think Jacksonville could end up salvaging the season if it were to beat Indianapolis. Jacksonville has won the home-and-home series once (2011).

The NFL is back in town as the Indianapolis Colts take on the Jacksonville Jaguars at Wembley on Sunday. Indy is now 1-2 on the season while hitting the over in two of the three games. This could be the week that the Jaguars top the 70-yard figure for the first time this season. "It's just full strength isn't there yet". Previous year they left on a Thursday and they ended up winning.

I think Andrew Luck is going to eat up this defense on Sunday so it'll be on the offense, and specifically Bortles, to keep up and try to outscore the Colts. Each passed for more than 800 yards in the first three games this year. It's a testament to Frank, his work ethic, his passion for this game, his athletic ability, his durability, his availability and his reliability. The Colts defeated the Jaguars 23-3. With the various sights and landmarks that London has to offer, Pagano isn't going to let his team get distracted before their big game, per Mike Wells of ESPN.com. "We are very appreciative of the strong and growing fan support, not only for the games, but for all of the related National Football League events we host in the United Kingdom throughout the year". Then, instead of spending almost an entire week in London, they went three days ahead of the game last season. The secondary hasn't been all bad as it held Rodgers to less than 200 yards and Flacco to 214.

And while it's not a hard and fast rule by any means, teams that are reeling heading into these overseas trips tend not to pull it together before coming home.

The Jacksonville Jaguars, meanwhile, have spent big on their defence in the off-season, with Super Bowl winning defensive lineman Malik Jackson among the biggest signings. Safeties Clayton Geathers and T.J. Green have become an effective duo in shutting down passing attacks while cornerback Vontae Davis continues to fight through an ankle injury.

Through three games, the No. 3 overall pick of the 2014 draft has thrown five touchdowns with six interceptions and lost a fumble.

PLAYER SPOTLIGHT: Colts OG Joe Haeg.

Defensive tackle Kendall Langford is one of several Colts who have played in London before, and he said too much is made of the rigors of travel.

While he didn't play in the December 13, 2015, defeat to the Jaguars, Castonzo said the entire team remembers the embarrassment of letting the Jaguars score a touchdown on every single second-half possession.

COLTS LB Erik Walden delivered 2 huge strip-sacks in Week 3 win, while fellow LB Sio Moore registered 8 tackles (team-leading 26). Hilton for a 63-yard touchdown with 1:17 remaining in the game. Tight end Julius Thomas has five TDs in three games vs. Indy. Last year the league signed a 10-year partnership with the Premier League's Tottenham, pledging to play a minimum of two games per year at its new stadium, which is slated to open in 2018, plus at least two at Wembley through 2020.

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