First half goals from Christian Eriksen and Dele Alli at White Hart Lane gave Mauricio Pochettino's side the cushion they needed to hold onto victory after James Ward-Prowse halved the deficit early in the second half.
Mauricio Pochettino, the Tottenham manager, declined to disclose how Walker picked up the injury during his pre-match press conference today.
Kane is sidelined for several weeks with ankle ligament damage sustained against Millwall in the FA Cup quarter-finals last weekend.
"He (Janssen) will now have the possibility to play more and be more involved".
"I think (Son's performance) was good". Let's break down three key ways the club can adapt to their new striker.
It was an examination that Spurs passed, demonstrating a clinical edge in the first-half and then riding ripples of Southampton pressure in the second-half.
Southampton would need to take 30 points out of a possible 36 from their final 12 league matches to equal last season's final points total of 63.
Christian Eriksen has netted three goals in three Premier League games against Southampton at White Hart Lane. This season they have made a ferocious 19.1 tackles per game (the league's third highest figure), 13.8 interceptions and 11.7 fouls, while no other Premier League team has blocked anywhere near as many passes.
It was a great chance and would prove a costly miss for the visitors as just past the half-hour mark and Tottenham won a penalty.
Southampton: Forster, Cedric, Yoshida, Stephens, Bertrand, Davis, Romeu, Ward-Prowse, Tadic, Gabbiadini, Redmond.
In the Round 22 Southampton played again on the road against Sunderland and scored 4 goals as well, which should be a decent indication of what we can expect come Sunday.
Spurs came closest to adding another goal as substitute Vincent Janssen led a counterattack and forced another good save from Forster. "Lately we've been in good form, scoring lots of goals and they have played a part in us achieving that".
Although Gabbiadini's unbelievable shooting has helped hugely in this department of late, Southampton's biggest problem remains converting their chances.
It was a marvellous goal, too, as Eriksen marauded through central midfield before letting fly and dispatching a strike into the far left corner of the Southampton goal.