Tim Farron, the Lib Dem leader, said Mrs May was putting together a Brexit plan to appease Nigel Farage and Paul Nuttall, the Ukip leader, ...
There wasn't a Natalie in sight but that didn't stop Nuttall from going back to the name on more than one occasion as he discussed the subject of an Australian-style points system for migrants.
In the first opening statement of the debate, the Plaid Cymru leader began by saying: "I have a message for the Prime Minister, who I'm sure is watching tonight".
Nuttall's first reference to "Natalie" was early in the two-hour debate but it was immediately identified as the likely highlight of an exchange neither Theresa May nor Jeremy Corbyn opted to attend.
But the UKIP leader didn't help his cause when on two occasions during the debate he called Leanne Wood "Natalie", presumably confusing her with former Green Party leader Natalie Bennett.
"It's my fault", Nuttall replied.
Mr Nuttall made the same gaffe moments later, saying: "I think that Natalie's absolutely right, what we need to do is".
Nuttall, the only pro-Brexit voice in a debate that opened with a question on how Britain should approach the negotiations, said he was not a representative of the prime minister. "I think there will be some sort of dodgy deal over freedom of movement as well and I think she will capitulate and we will pay a divorce bill".
Nuttall, Wood, Lucas and Sturgeon were left to fight it out alongside Tim Farron.
And she said that the Green Party would hold another vote in a move created to derail Brexit.
He went on to describe his party as "back-up" for Mrs May and Brexit Secretary David Davis, holding their feet to the fire and stopping them "backsliding" from full Brexit.
Ms Sturgeon, Scotland's First Minister, accused Theresa May of pursing "a hard, extreme Brexit". Labour leader Jeremy Corbyyn also declined an invitation to participate in the debate. "We need strong opposition - holding a Tory government to account, keeping them in check and standing up for the values we hold dear: values of social justice, tolerance and community", Sturgeon said.
"Do you not think the British people deserve to see me and you debate live and on television?" he wrote.
ITV had said it would not accept representatives, or spokespeople, to appear in the place of the party leaders.
The Conservative chair, Patrick McLoughlin, called the debate "a glimpse of the chaos you could get in just three weeks with all the other parties propping up Jeremy Corbyn as prime minister".
The leaders of five political parties have taken part in a live general election TV debate.