Earlier this week, McConnell, a Kentucky Republican, blamed the defeat partly on Trump's inexperience, saying the president has "excessive expectations" and doesn't fully understand how Congress works. That was apparent when White House social media director Dan Scavino tweeted from his private account Wednesday morning that McConnell was giving "more excuses" and that he "must have needed another 4 years-in addition to the 7 years-to repeal and replace Obamacare".
Trump said, "You can ask the question" about whether Majority Leader Mitch McConnell should remain in his position if he cannot pass a plan to repeal and replace health care, change the tax code and move an infrastructure proposal. "Tell Senate Republicans to replace him now!"
For his part, McConnell's statement was surprising because he is typically among the capital's most guarded politicians.
A study by a nonpartisan group says the Trump administration's own actions are triggering double-digit premium increases on individual health insurance policies purchased by many consumers. How is any legislation going to get passed and signed into law if the Republican president and the Republican Senate Majority Leader are both pointing fingers at the other guy for their failure?
Trump himself echoed Scavino with a Wednesday afternoon tweet.
"Why not done?" Trump wrote.
The relationship between Trump and McConnell began to sour soon after Senate Republicans were unable to come to an agreement on a package to repeal and replace Obamacare in late July.
Also joining the fray was Fox News Host Sean Hannity, a close Trump ally.
Hard-right conservatives have long assailed McConnell for being insufficiently ideological.
For one, Republicans have never really reached a consensus about upending health care.
Remember that for everything that Trump wants going forward - tax reform, funding for the border wall, maybe even another shot at health care - he needs McConnell.
Later in the day, as if one attack were not enough, Trump delivered another jab on Twitter, demanding from his vacation that McConnell "get back to work". Luther Strange, the majority leader's preferred candidate in this month's GOP primary race to succeed Attorney General Jeff Sessions.