Johnson's x-rays came back negative but he'll undergo an MRI on Monday to determine the extent of the injury.
On Monday, Cardinals coach Bruce Arians said Johnson's injury is similar to a wrist injury suffered by rookie running back T.J. Logan during the preseason.
"Obviously I've been there before", fellow running back Andre Ellington said.
So with the Cardinals now dealing with not having their star running back for an extended period, what should fantasy football owners do?
Chris Johnson played in just four games last season before suffering a groin injury that required surgery and landed him on injured reserve for the remainder of the year. I like the opportunity he'll get, even it won't be a huge workload on a weekly basis. Before he was hurt, he had 25 carries for 95 yards as the primary backup.
Re-signing Chris Johnson, who was cut on September 1, could be an option, Arians said. While he will return at some point this season, he is expected to miss significant time. Johnson had also taken a hard hit after a completion a couple minutes earlier and was tended to by medical staff.
Johnson accounted for 2,118 yards and 373 touches (293 rushes, 80 receptions) in 2016.
Chris Johnson will get some playing time probably until they realize he's ineffective.
"Kerwynn [Williams] was good", Arians said. Teams with IR slots should certainly stash Johnson for a potential playoff run, but teams with short benches have a tough decision on their hands.