The form of the likes of Alex Iwobi and Jack Wilshere has certainly helped fill the void but Ozil is back in training and could return against Watford on Saturday.
Wenger said: "You need players who have quality".
The striker turned pundit and tipster admits to being a big admirer of Hornets boss Marco Silva, ans the start his side have made to the Premier League season.
Ozil's agent Erkut Sogut said talks with Arsenal were "going in a positive way" this week, and Wenger affirmed that view.
"We live in a world where people have opinions, and sometimes they are right and sometimes they are not always proven right on the longer period". We beat Man City in the FA Cup semi-final and Chelsea in the final and he played as well.
"I would say you have in every generation a player who carries the pressure of expectation of a nation", Wenger told reporters during Friday's press conference.
'You can always find the example but it's true we have done well recently'.
"That's when I knew he was a great manager".
Defender Shkodran Mustafi will be out for up to six weeks because of a thigh injury sustained during the worldwide break. I genuinely think he wants to stay. 'Of course, he is important but I have many players'.
"Our chairman Steve Williams has been really working hard to raise funds for a new 4G pitch, stand and academy for the kids, so I am hopeful with the help of people like Paul, we can raise the profile a lot".
He also wanted assurances he would operate as a No 10 and, since signing his own contract extension, the manager has become tightly Wednesday to his 3-4-2-1 system which eliminates the traditional playmaker's role.
Arsenal are now fifth the Premier League table ahead of their clash at Watford.