The Bucks would regain the lead courtesy of some nice moves around the rim by Greg Monroe, but the Celtics continued to stay within striking distance with the quarter ending with Boston ahead 72-69 following a buzzer-beating basket from Al Horford as time expired.
But Antetokounmpo presented the ultimate challenge for Horford, with the Greek Freak coming in having scored at least 30 points in each of Milwaukee's first four games.
Leading to such a decision by the Eastern Conference franchise, the Bucks are celebrating the team's 50th season in 2017-18. The Bucks will move into a new arena next season.
The Bucks led, 44-43, at halftime, but Kyrie provided a game-high 16 points on 6-of-9 shooting.
Milwaukee's Giannis Antetokounmpo came into the game leading the National Basketball Association in scoring at 36.5 points per game but was held below 30 points for the first time this season.
Horford spent a majority of the game matched up with Giannis Antetokounmpo on the defensive end of the court.
Informed it was just a one-time deal - the Bucks plan to repaint the floor and send it to their G-League affiliate - Irving added, "I'm glad I was part of that historic event". "In the second half, things opened up a little bit". "It's trying to teach me that it can all be taken in an instant".
Smart hit a pair of 3-pointers midway through the final period to give the Celtics an 82-72 lead.
The Celtics and Bucks will be squaring off at 8 p.m.
"They packed the paint and made it extremely tough on Giannis", Bucks coach Jason Kidd said. "But our focus has to be on playing the game". "It's fun to be part of these types of games, when you talk about the history of this building and what it has meant to Milwaukee and the NBA", Stevens said.