Liverpool FC forward Sadio Mane will be unavailable for the visit of Huddersfield Town on October 28.
Liverpool have now confirmed that Mane has suffered a significant hamstring injury and will be out of action fro up to six weeks while he recovers.
The injury is especially badly timed for Klopp with Liverpool's bitter rivals Manchester United visiting Anfield on Saturday. The six-week time-frame rules him out of seven Liverpool matches, with a Champions League clash at Sevilla and a Premier League match with Chelsea following swiftly after.
Having worked hard to get back to fitness this term, Mane was sent off at Manchester City on 9 September, resulting in a three-match ban.
Since the start of last season with Mane in the team, they have won 19 of 32 Premier League games and averaged 2.2 goals and 2.1 points per match in the process. Mane, who was among a 30-man shortlist for.
Mane will miss the visit of United on Saturday as the Premier League returns following the global break, plus a number of other potentially crucial encounters, including the trip to Tottenham on October 22.