Hughes, who was a team captain on the popular United Kingdom music-based comedy quiz show "Never Mind the Buzzcocks" between 1996 and 2002, also briefly starred his own sitcom "Sean's Show" on Channel 4.
His last tweet to his 49,000 followers on October 8 simply read, "In hospital". He was the first comic I ever saw live. Very talented comic, loved & respected.
Djalili said: 'Deeply saddened to hear Sean Hughes died this morning aged 51.
His former-promoter Richard Bucknall told Beyond the Joke: "He was a pioneering, groundbreaking comedian who changed comedy with that live show".
Matt continued: 'He'd been unwell, but when I started out on the comedy circuit about 25 years ago, Sean was one of the biggest stars'.
Dee said he was "very sad" to hear of the news of Hughes's death. "I always enjoyed the mad tangents our conversations would take".
Mentioning other comedians who have died, Davies added: "Sean Hughes with Linda Smith, Felix Dexter, Caroline Ahearne, and Malcolm Hardee as compere". Very talented comic, loved & respected. That's no age. One of the Irish comedy trailblazers in the United Kingdom'.