De la Huerta, 33, told the magazine the first alleged rape happened in November 2010. "Then he pushed me onto the bed and his trousers were down and he lifted up my skirt".
The world-famous movie producer has come under fire, with dozens of women accusing him of sexually harassing or attacking them.
By the end of 2010, de la Huerta said she started drinking heavily and fell into depression.
Chief of Detectives Robert Boyce said police found the "Boardwalk Empire" actress' story believable and that if Weinstein were now in NY and the assault allegation had just happened, "we'd go right away and make the arrest".
The accuser, an actress who came forward 10 days ago, told NYPD investigators Weinstein raped her in Lower Manhattan on two different occasions that year, police sources said.
The Boardwalk Empire made the revelations in an interview with Vanity Fair. "The second time, I was terrified of him", she said.
"He finished what he did, and he told me he'd be calling me", she said. "It happened very quickly." de la Huerta said.
She told CBS that Weinstein offered to give her a ride back to her apartment after a party in October 2010 because they lived in the same neighborhood. "The investigation is ongoing", Ryan said.
"We have an actual case here, so we are happy with where the investigation is right now".
The investigation comes a month after The New York Times published an expose of sexual harassment allegations against Weinstein, leading to his firing from the company he co-founded and his expulsion from the organization that bestows the Academy Awards.
The actress' attorney provided material to New York District Attorney Maxine B. Rosenthal, who is considering filing charges against the movie mogul.
Weinstein's representative, Sallie Hofmeister, says the 65-year-old Oscar victor denies any allegations of non-consensual sex.