UPDATE (9:50 am) Up to 150 acres and 0% contained.
There were no other immediate reports of injuries.
As the fire expanded and jumped south of the 210 Freeway, so did the mandatory evacuation area.
More than 1,000 firefighters are trying to battle the blaze but can not enter the area "due to the intensity of the fire", county officials said.
Residents living south of Mulholland, east of the 405, north of Sunset Boulevard, and west of Roscomare Road were told to leave their homes.
Mandatory evacuation orders are in place for Lopez Canyon, Kagel Canyon and Little Tujunga Canyon, Los Angeles Police Department Officer Cabrera said.
Two firefighters were injured, officials said.
L.A. Mayor Eric Garcetti declared a local emergency in response to the Creek Fire.
For the second time in as many months, the East Contra Costa Fire Protection District will be sending a strike team out of District to assist other agencies in fighting fires.
"These are days that break your heart; but these are also days that show the resilience of our city, " Garcetti said. The Skirball Fire encompasses parts of Bel Air, Holmby Hills, and Brentwood, and is affecting the surrounding food-friendly neighborhoods, including Westwood.
An unknown number of homes were destroyed by the blaze, according to LAFD.
LAFD Chief Ralph Terrazas noted that red flag conditions are expected to remain in effect at least through Friday, with gusting Santa Ana winds presenting a continuing danger of rapidly spreading blazes. The fire consumed 4,000 acres by 8:30 a.m. and blanketed 11,000 acres with zero containment by early afternoon. Winds in the area were blowing at 25 miles per hour. Helicopters on sight. Evacuation centers set up at rec centers.
"Driving to LAX just as they're closing the 405 for this roaring hillside fire near the Getty exit", Rebecca Keegan, the Vanity Fair correspondent tweeted Wednesday.
The 405 is closed in both directions from the 10 to the 101. The closure led to massive congestion on many streets in the San Fernando Valley and in West Los Angeles.