There has been no official Israeli comment on the attack, however, the message is clear, that Iranian bases will not be tolerated, as senior officials in Israel have stated.
The Syrian Observatory for Human Rights said heavy explosions were heard in the area and electricity was cut off throughout Damascus.
Israeli aircraft on Friday fired several missiles at Iranian military base outside the Syrian capital of Damascus, Sky News Arabia and other news media reported.
Some videos that emerged on social media are claiming to show the moment when the Israeli missiles were intercepted by Syrian Air Defense.
The Israeli air force has said it struck arms convoys of the Syrian military and Lebanon's Hezbollah almost 100 times during more than six years of the Syrian war.
Syrian state TV reports that the attack caused damage but two missiles were intercepted.
The Syrian conflict began in March 2011 against the Assad government, but it morphed into a civil war that has killed hundreds of thousands of people.
Israel has reportedly carried out airstrikes outside the Syrian capital Damascus overnight, according to local sources.
It says that Israeli fighter jet was flying at a low altitude over Lebanon's Baalbek region near Syrian border when Syrian missiles were launched.
In September, Israeli warplanes hit a military position near the Mediterranean coast in western Syria, killing two soldiers and causing material damage.