So is she running?
A representative for Winfrey did not reply to a request Monday for comment from The Associated Press.
The Democratic race for president won't officially begin until after the 2018 midterms, but many potential candidates are already jostling for position and making trips to Iowa.
The touchstone of her speech was the #MeToo movement.
Elisabeth Moss touched on some of the same ideas in her acceptance speech for Best Actress in a TV Drama for portraying June in A Handmaid's Tale.
Many liberal-leaning celebrities and viewers certainly heard it that way.
For now, it's all just talk.
"It is the insatiable dedication to uncovering the absolute truth that keeps us from turning a blind eye to corruption and to injustice, to tyrants and victims and secrets and lies", she said.
Since then, Winfrey endorsed Hillary Clinton in 2016.
"I remember his tie, it was white, and of course his skin was black, and I had never seen a black man being celebrated like that", she said.
"It came from such a pure instinctive place", she said on the podcast.
Winfrey has deep pockets, an even deeper well of charisma, and instant name recognition, thanks to decades on "The Oprah Winfrey Show".
She dedicated her win to her castmates, daughters and mother, saying: "Wow, the power of women".
Hollywood's loathing of Trump and bafflement that a crass-talking reality star with no previous government experience could win the presidency have fueled talk of well, why not another television star, only one with the "right" politics? "She stopped going out at night "'cause I was afraid that maybe something else might happen".
Winfrey laughed while the studio audience applauded.
Such oral love in front of so many people would make the recipients a bit uncomfortable, you would think.
Earlier in the evening, Winfrey had been asked to trim her speech by three minutes.
Oprah Winfrey is "actively thinking" about running for president, according to a new report.
With a orators' practiced cadence, Winfrey added, "But their time is up".
Fired from House of Cards and Ridley Scott's All the Money in the World after multiple allegations of sexual misconduct and assault, Spacey, along with disgraced producer Harvey Weinstein and director Woody Allen, was a particularly pointed punchline during the Hollywood Foreign Press Association's annual awards.
She also expressed her gratitude to the press, which she said "is under siege these days" and which she says she values more than ever.
Ever outspoken in speeches and social media, she stayed away from partisanship.
Notably left empty-handed were Christopher Nolan's "Dunkirk", Jordan Peele's horror sensation "Get Out" and Steven Spielberg's "The Post", starring Tom Hanks and Meryl Streep.
Calling Winfrey's words a "barnburner", Streep told the Post that the OWN founder runs "a major company". "But now she doesn't have a choice".
In response to a Seth Meyers joke about Winfrey at the Golden Globe Awards on Sunday night, NBC tweeted "Nothing but respect for OUR future president" to almost 1.8 million followers.
Meyers also jokingly encouraged Oprah Winfrey to run for president against Donald Trump.
"I will never have to know the answer to that, because I will never run for public office", she said. You do not have what it takes!' Meyers said on Sunday.