The Reds have already driven a sizeable wedge between themselves and their Portuguese opponents by sealing a 5-0 away win last time out, but still need to complete the job at Anfield.
The Merseyside club produced a lacklustre display in a 0-0 draw that saw them progress to the quarter-finals of Europe's most prestigious competition.
Liverpool manager Jurgen Klopp praised their Dutch defender, Vigil Van Dijk, for his contributions with the team since he joined them in January from Southampton.
Once all the games have been completed, the draw will take place live at UEFA's headquarters in Switzerland on Friday 16 March at 11 am GMT.
Klopp knows that nothing will come easy for his side and, with as many as four other Premier League sides possibly in the draw, that the possibility of facing an English rival exists.
"I think this year we belong there to be honest, it should not be a big surprise".
"The next round will be very hard, I think that's clear", he said. Porto coach Sergio Conceicao made 10 changes from the first leg, but top-scorer Vincent Aboubakar was one of those to come back into the side having missed the first leg through injury.
A legend of the game is appreciated everywhere he goes and that's exactly what happened when Porto custodian Iker Casillas visited Anfield to take on Liverpool in a UEFA Champions League tie on Tuesday night.
So the game against Porto represented a fantastic opportunity to rest the key players - not that Klopp exactly took it. You wouldn't want to play Liverpool, ' Ferdinand said while featuring as a pundit on BT Sport.
Liverpool continued to control possession, though, and they nearly added to their first-leg lead shortly before the hour mark when Firmino raced through on goal only to be denied by a sliding challenge from Felipe.