Curry, who missed most of December with a right ankle sprain, reinjured the ankle just over two minutes into Friday's (AEDT) game against the Spurs.
With Stephen Curry going down with an ankle injury just two minutes into the game, Durant carried the load in a close win over the Spurs.
The two-time MVP hobbled over to the Warriors bench, but despite coming back onto the court to shoot his two free-throws after being fouled on the play, he immediately left the game and didn't return.
Worryingly for the Dubs, this is the fourth injury Steph has had to his right ankle this season and the second in the last week after he suffered a minor sprain when landing on teammate Zaza Pachulia's foot against the Atlanta Hawks.
Second, can the Warriors thrive without Curry?
Golden State is 51-14, now in second in the Western Conference behind the Houston Rockets. They've said time and again that their main goal is simply to go into the playoffs healthy and playing well, with the No. 1 seed out West being a distant third on the priority list.
Kevin Durant, Draymond Green and Klay Thompson all are due at Target Center Sunday at 2:30 p.m.to play a Wolves team that has lost three consecutive games for the first time this season. But without him, they become a merely great team, and one that would - at a minimum - be given a hell of a run by the Rockets and some of the league's other elite teams.
"We still have three all-stars when Steph goes down", Kerr said.
So when the Warriors left for Portland early Friday morning, Curry stayed behind to rest and rehabilitate his injured ankle.
Curry makes the Warriors a special team.