"European banks should safeguard trade with the Islamic Republic", Khamenei said.
Iran said it is waiting for concrete measures from the European Union nations before it decides whether the deal can be saved, while threatening to restart its uranium enrichment program at an "industrial level" if not.
British, Chinese, French, German and Russian officials will try to flesh out with Iran's deputy foreign minister a strategy to save the deal by keeping oil and investment flowing, while circumventing US sanctions that risk hurting the economy.
But U.S. Secretary of State Mike Pompeo on Monday threatened the Islamic Republic with "the strongest sanctions in history" if it did not change its behavior in the Middle East.
Iran's Supreme Leader Ayatollah Khamenei has issued five demands to the European Union (EU)-including Europe guaranteeing Iran's oil will be completely sold-that European leaders could find quite hard to meet.
Iran wants European powers to present it with measures by the end of May to compensate it for the U.S. decision to abandon the 2015 nuclear deal, a senior official said Friday, and Tehran would decide within weeks whether to quit the accord.
A senior Iranian official rejected any attempt to link the deal, known as the Joint Comprehensive Plan of Action (JCPOA) to other such issues, saying it would mean "we lose JCPOA and we (would) make the other issues even more complicated to resolve", adding that it was pointless for the Europeans to try to "appease" Trump. "We do not want to start a fight with these three countries [France, Germany and the United Kingdom] but we don't trust them either".
The ayatollah may have staked out a deliberately demanding position to give more room for the Iranian foreign minister, Javad Zarif, to appear conciliatory in his own meetings with the Europeans to try to save the nuclear agreement.
Press reports have previously said that Iran wants to develop nuclear-powered ships or submarines.
He said Iran could no longer have any dealings with the USA, saying: "The Islamic Republic cannot deal with a government that easily violates an worldwide treaty, withdraws its signature and in a theatrical show brags about its withdrawal on television".
Europeans [must] clearly oppose all American sanctions against Iran.
"Ultimately, this stance is likely to put the region in further danger than it is today", he said.
Since the deal came into effect, Iran has twice inched over the agreed volume of heavy water, a reactor coolant. "The important thing is that Tehran also abides by its obligations, as confirmed by the IAEA (International Atomic Energy Agency)".
"The current USA president will meet the same fate as his predecessors.and will vanish from history", he said.
"After the US left the JCPOA, Khamenei ordered Iran's President Rouhani to get guarantees from the West about continuing to facilitate trade".