Cardiff start at Bournemouth while Fulham, who secured their place in the top flight via a Wembley play-off final win over Aston Villa start the league season at home to Crystal Palace.
I am hoping that Emery gets off to a great start, and this game will be important in deciding who starts his first Premier League game.
It is unclear if Spurs' new £850m stadium will be available in time for the start of the new campaign, and they must confirm by Friday if they need to use Wembley for any home fixtures. Arsene Wenger used to give the players four weeks off at least, but it is a new era for Arsenal with a new coach coming into the club.
After the opening-weekend game at Etihad Stadium, the Gunners travel to fellow top-six contenders Chelsea.
The Premier League fixtures for the 2018-19 season were published on Thursday and the Arsenal-Man City game was the standout on the opening weekend. Arsenal and Tottenham will be at the Emirates on the weekend of December 1, with the return on March 2.
Games against Fulham, Liverpool and Watford will see the club endure a busy Christmas period before Manchester United make the trip to St James' Park on New Years' Day.
It could hardly be a more arduous start to the domestic campaign for Emery, and fans gave the full range of emotions on social media in response...
"The most important game is the north London derby", he said.