Initial reports say his scooter collided with a vehicle.
Despite the potential severity of the accident, after receiving an MRI Clooney was discharged from the hospital at 10 a.m.
A local police officer confirmed to CNN he spoke to Clooney after the accident and the actor said he was "fine". A photo of a Mercedes-Benz E-Class Wagon with a smashed windshield and a nearby scooter would seem to suggest that Clooney hit the windshield in the impact. Add George Clooney as an interest to stay up to date on the latest George Clooney news, video, and analysis from ABC News.
Earlier this year, actor Will Ferrell was caught up in a two-car crash in California.
In the hospital, he was joined by his wife Amal and they left the venue together in a private auto.
Clooney will star in and co-direct the limited series, which began filming in May.
The north-east coast of Sardinia is popular with the rich and famous, although Clooney is on location on the island to film a new mini-series, Catch 22. Clooney was reported treated at Palisades Medical Center in North Bergen, at the time of the incident.