Following news of the cabinet split, former England worldwide and 1986 World Cup Golden Boot victor Gary Lineker was among the first with a football jargon-laiden jibe comparing Johnson's resignation to a "transfer request".
A spokesman for Downing Street confirmed: "This afternoon, the Prime Minister accepted the resignation of Boris Johnson as Foreign Secretary".
The appointment of Hunt, the long-serving health minister, sees a close May ally replace the maverick Johnson, and could alter the Brexit balance of May's top ministerial team.
Johnson, who wrote in his resignation letter that the Brexit "dream is dying" and that Britain was headed for the "status of colony" under May's leadership, is seen as a potential challenger.
A handful of lawmakers who want a clean break from the European Union said privately they had submitted letters calling for a vote of confidence in May, though hadn't met the threshold of 48 needed to trigger such a ballot.
Loud applause could be heard at the end of the 1922 Committee meeting, which the PM attended for just over an hour.
Jacob Rees-Mogg told talkRADIO earlier today (July 10) that he did not know if any MPs had submitted a vote of no confidence.
There have been differences within the Conservatives over how far the United Kingdom should prioritise the economy by compromising on issues such as leaving the remit of the European Court of Justice and ending free movement of people.
Some Conservative Party lawmakers warned they would not tolerate a betrayal of Brexit.
"Before asking other employees to consider relocating, we will wait for further political and regulatory clarity in line with our overall post Brexit strategy", according to the memo.
Walkouts on Tuesday by a pair of little-known Tory vice-chairs, Ben Bradley and Maria Caulfield, did not have the impact of Johnson's resignation, and the party's campaign machine will roll on smoothly without them.
David Davis' decision to resign from the cabinet has left the government in chaos.
In an interview with Xinhua, Widdecombe said the plan fails to give Britain a "proper break" from the European Union (EU).
"In a vote of confidence in the House of Commons I would support the Prime Minister that's because I don't want to have another General Election, there isn't a vote of confidence in either case at the moment, I don't think many people want another election, we only had one a year ago". He tweeted the Prime Minister "doesn't have a majority for it and there's no reason why we'd vote for a hard Brexit for services".
According to the proposals agreed upon by the British government on Friday, the United Kingdom and the European Union ahead of Brexit would maintain "a common rule book for industrial goods and agricultural products", and London would commit to "ongoing harmonization" with European Union rules on goods to ensure frictionless trade at ports and the border with Ireland.
Strung from a zip wire high above London while clutching two British flags, a harness tightly gripping his suit, is how many will remember Mr Johnson.
Nadine Dorries, the outspoken Bedfordshire MP, said: "I think that we in this room, while being reasonable, need to feel some steel in our spines".
Mrs May told MPs that the plan agreed by the cabinet at Chequers was the basis of a "responsible and credible" offer to restart renegotiations with the EU.
He pointed out the only sign of a border is the different colour of road markings.