Arriving in the country earlier that day, the President's visit to the United Kingdom hasn't come with a lot of support from residents who plan to protest throughout his trip, already gathering outside the U.S. ambassador's residence in London where the couple are staying for the night.
Some Brexit supporters have cast May's Brexit plan as a betrayal, including lawmakers in her own deeply-divided party who have warned of a leadership challenge.
Top it off with the introduction of trade policies that have targeted some European industries - even though European nations are longtime friends accustomed to easy trade with the USA - and it is not surprising that Trump's itinerary will keep him out of central London on Friday, when large protests are planned.
Trump has been quick to criticize British society, telling a National Rifle Association convention in May that the British didn't have guns but had so much knife crime that one hospital was like a military war zone with its floors awash with blood, a false statement quickly rebutted by British physicians and politicians.
"You see what's going on throughout the world with immigration.I think that's why Brexit happened", he said. "People want to send a message to everyone fighting against this politics of hate, we all stand united together, and we will not allow the clock to be turned back to the darkest moments of human history".
The couple will also attend a black-tie dinner at Blenheim Palace in Oxfordshire hosted by Mrs May on Thursday evening and stay overnight at Winfield House in Regent's Park, which is the US Ambassador's residence in London.
"There is no stronger alliance than that of our special relationship with the U.S. and there will be no alliance more important in the years ahead", May said ahead of the visit.
Ahead of his arrival the PM said she would use the visit to "forge a strengthened, ambitious and future-proof trade partnership" with the U.S. after Brexit.
He touched down in Britain for his first official visit and has already brushed off mass protests by saying: "I think they like me a lot in the UK" and caused Theresa May a major new headache over Brexit. May said in remarks during a banquet on Thursday with Mr. Trump at Blenheim Palace, Churchill's birthplace.
The biggest protest will take place in central London on Friday when thousands are expected to take to the streets to join the "Stop Trump" march.
A campaign is also underway to get "American Idiot", a 2004 song by the USA punk rock band Green Day, to the top of the UK Singles Chart.
But British Prime Minister Theresa May is hoping his trip will boost the close ties between their two nations and help in forging a future free trade deal.
The two leaders will hold talks the following day at Chequers, the 16th-century manor house which is the prime minister's official country residence which will focus on Russian Federation, trade, Brexit and Middle East.
Later, Trump will go to Windsor Castle for tea with 92-year-old Queen Elizabeth.
On Friday night, the president will travel to Scotland, Turnberry, the South Ayrshire golf resort he bought in 2014.