Now there's a fresh wound - and a massive one - early in the 2018 season.
While the Redskins have quality depth at running back thanks to the likes of Kapri Bibbs, Samaje Perine and Rob Kelley, the idea was to pair a first-round talent like Guice with Chris Thompson right away. Past year at LSU, Guice was hampered by a hyperextended knee, limiting his snaps and forcing him to miss a game.
Per NFL's Ian Rapoport, there was hope Guice had only suffered an MCL injury, but the young running back's walk off the plane "was concerning".
Selected in the second round of this year's draft, former LSU standout Guice went down awkwardly as he was tackled from behind on an impressive 34-yard scamper negated by a holding penalty.
In 2012, Adrian Peterson notably returned from the injury and had a career-high 2,097 yards en route to being named the league's MVP.
Washington has a lot of imperfect running backs, and only Guice was a potential three-down player. The team announced the prognosis Friday following an MRI, saying Guice should make a full recovery and be ready to play in 2019.
Brady, 41, signed a two-year, $41m contract prior to last season.
Guice was injured in Washington's preseason opener at New England.
The team said tight end Manasseh Garner, a long shot to make the roster, is out for the season with an ACL injury.