The controversial SpaceX and Tesla billionaire smoked a joint during a wide-ranging two and a half hour chat Joe Rogan Experience comedy podcast, which covered everything from artificial intelligence and its impact on humankind to flame throwers and social media.
"You probably can't because of stockholders", Rogan asked as Musk chuckled.
Musk stunned investors last month with tweets saying he had funding to take the company private for $420 (£323) a share. Shares of electric vehicle maker Tesla Inc. tumbled over 9 percent as the markets opened today after the CEO smoked marijuana during a YouTube video podcast and the company's accounting chief left after a month on the job.
"I think I tried one once", Musk replied with a laugh. "Actually, they're pretty good at science in China, I have to say", Musk said, adding, "The mayor of Beijing has, I believe, an environmental engineering degree, and the deputy mayor has a physics degree".
Accounting officer Dave Morton's resignation was announced in an official filing with United States regulator the Securities and Exchange Commission.
Tesla did not immediately respond to ABC News' request for comment. In an interview with Bloomberg Television, he called for the company to split up the chairman and CEO jobs - Musk has served both roles since October 2008.
The company, hurt in the past month by Musk's high-profile U-turn on a deal to take it private, said Chief Accounting Officer Dave Morton had resigned, citing discomfort with the level of public attention and pace of work. That tweet prompted controversy and an SEC investigation.
"I think people should be nicer to each other", he said. "And then other people asked us to build tunnels so we said yes in a few cases", said Musk discussing the Boring Company.
Mr Musk has said the company is producing more than 5,000 Model 3 electric cars per week, and cash generated from the sales will bring sustained quarterly profits.
Musk's behaviour has created concern among Tesla shareholders who have questioned his leadership ability following a series of controversies in recent months.
The tumult comes as Tesla has been ramping up production of its Model 3 electric auto, which is seen as a make-or-break effort for the company.