According to multiple reports, their auto hit a rock in the road which sent them the vehicle out of control and ultimately led to their deaths.
Castillo saw fairly regular action at second base with the Pirates from 2004-07 and split the 2008 season between the Astros and Giants. Some reports say the vehicle actually struck the rock.
"We are living through a terrible tragedy", the Cardenales said on Twitter. Other tributes and statements also began to pour in on social media.
"We are deeply saddened to hear of the passing of former Angel Luis Valbuena and former Major League Baseball infielder José Castillo". "During his two seasons in Houston, Luis was an extremely popular player with his teammates and the Astros staff".
The 33-year-old Valbuena and 37-year-old Castillo died late Thursday when their SUV crashed as it tried to veer around an object placed in the road, Yaracuy state Gov. Julio Leon Heredia said on his Twitter account. Off the field, he was a warm and friendly presence to all who interacted with him.
CubsHQ.com would like to send our most heartfelt condolences and prayers to the family and friends of Luis Valbuena and Jose Castillo.
Valbuena was known throughout baseball for his bat flips and overall joy for the game, as the veteran infielder even pimped his walks.