The timing appearing a little odd though as the Saints got what looks a credible 2-2 draw with Man Utd at the weekend.
Hughes arrived at his former team in March on a short-term contract and helped the south coast club avoid relegation last season by securing a 17th place finish.
The result means that United remain rooted in 8th, but are now an alarming eight points adrift of the top-four, and a truly staggering 16 points behind table-toppers Man City - after only 14 matches.
Hughes spent less than nine months in charge of the team, with his final game being the 2-2 draw against Manchester United on Saturday (Sunday NZ Time) in which Southampton squandered a two-goal lead.
However, they were leading 2-0 and after making it 10 Premier League games without a win, it leaves them in 18th, only one point off the bottom. It is hard to see him remaining in the Premier League.
Assistant First Team Manager Mark Bowen and Assistant First Team Coach Eddie Niedzwiecki have also left the club.
"Because we lost so many balls in midfield, we lost so many balls in our transition to the last third, it was hard to have that continuity".
Davis will have his first litmus test against Tottenham on Wednesday, December 5, at the Wembley Stadium.
Betfair spokesperson Katie Baylis said: "With confirmation Hughes has been given the boot from Southampton, attention turns to who will take over".