The snow will become lighter Friday and taper off west to east.
The Minnesota State Patrol reported that between 6 p.m. Wednesday and 8 a.m. Thursday there were 270 crashes with 20 causing injury, 270 vehicle spinouts and eight jackknifed semis statewide.
In Mankato, snow is expected to begin falling mainly after noon on Wednesday.
The rain, and snow to the north, will move into the Ohio Valley and reach north to New England overnight Thursday into Friday morning.
The Twin Cities is predicted to see between 1 to 3 inches of snow by Wednesday afternoon.
Rapidly accumulating snow could make travel hard over some locations. The snow will make it to the metro after sunset, likely after most, if not all, of the evening rush.
For those still digging out, Sunday could provide a high of 27 degrees beneath partly cloudy skies before colder conditions return for year's end.
Once the fog lifts, Christmas will be the best day for traveling this week.
They expect the low-pressure storm system to drop at least six inches of snow from northeastern Colorado to eastern North and South Dakota before sweeping through northern Minnesota and the Upper Peninsula of MI.
Statewide, northwest winds are expected to gust in excess of 30 miles per hour.
According to Edwards' forecast, the heaviest snowfall will affect central Nebraska as the storm moves from there through eastern South Dakota and into central Minnesota. Central and western Nebraska roads could have a layer of ice beneath packed snow. The heavy snow and high-powered winds "could create very risky travel conditions", Edwards says, with some areas experiencing near-blizzard conditions and winds between 20 and 30 miles per hour.
Highs drop into the low 20s on Friday with overnight lows in the single digits.