Chinese scientists say that the monkeys are showing a wide range of circadian disorder characteristics including reduced sleep time, increased anxiety and depression as well as schizophrenia-like behaviour.
Liu Zhen, a researcher of the Institute of Neuroscience of Chinese Academy of Sciences, introduces relative research achievements about the cloned monkeys.
Scientists used the same somatic cell nuclear transfer method that was utilized when Zhong Zhong and Hua Hua were cloned in late 2017. He is brought, if he is disturbed, people with sleep disorders, Depression, Diabetes, cancer, and diseases such as Alzheimer's disease.
ION, CAS is following strict global guidelines for animal research. The monkey's fibroblasts were used to make the five cloned monkeys.
China's ministry of science and technology has reportedly ordered research institutes to halt any of He's projects they're involved in.
He embraced the tool, called CRISPR, and previous year rocked an worldwide conference with the claim that he had helped make the world's first gene-edited babies, despite a clear scientific consensus that making genetic changes that could be passed to future generations should not be attempted at this point.
"Our BMAL1 knock-out monkeys thus could be used to study the disease pathogenesis as well as therapeutic treatments".
He said that the research signified the maturing of China's somatic cell cloning. He Jiankui already made the headlines when he announced in November 2018 that he carried out a clinical trial where he edited the genes of embryos. This egg then went on to develop into an embryo, and this was then transplanted into a female macaque that later gave birth to the monkey clones. "It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible", Qiang Sun from the institute, was quoted as saying.
The Chinese researchers aim to better the technique used to boost cloning efficiency. The group is expecting more macaque clones carrying disease-causing gene mutations to be generated in the coming years.
She told Newsweek that while the studies presented said the team followed "strict worldwide guidelines for animal research" many aspects of the monkeys' welfare remain unclear.
The method was the same used to produce the celebrated sheep "Dolly" more than 20 years ago.
In the future, the team plans would focus on cloning monkey models with different brain diseases. Furthermore, the study is being supervised by the institute's ethics panel.
"The use of primates in scientific research and testing is a matter of extreme concern to the animal protection community and to members of the public around the world", said Dr Penny Hawkins, RSPCA's Head of Research Animals told The Sun.