The charities - which work to promote the arts, access to education, support for women and animal welfare - were chosen to reflect causes Meghan has previously been associated with.
Kensington Palace said that over the past 12 months Meghan "has held meetings and conducted private visits" with each of her four new charities or organisations.
After holding the role for the last 45 years, Her Majesty the Queen has passed on the patronage to the Duchess of Sussex. "It's not just about donating your clothes and seeing where they land, but really being part of each other's success stories as women", she said.
Finally, there is the Mayhew, a London-based animal welfare organization, flawless for a woman who has adopted several rescue dogs.
The avid animal lover, who is raising two rescue dogs with Harry, is also the patron for Mayhew.
The Duchess of Sussex's royal patronages have been announced and they include two organisations that the Queen once looked over. In 1970, when Princess Anne, then just 20 and beginning her life as a working royal, became president of Save the Children, it was a relatively small aid organization. She's also worked with the United Nations, advocating for women's rights.
During the visit, Meghan spoke to women and help style them.
"Members of the royal family can use their patronages to shape their legacy as members of the royal family", Murphy told ABC News.
The Duchess of Sussex is set to visit animal charity Mayhew next Wednesday.
After becoming a member of the royal family previous year in September, Markle released the cookbook Together with women of the Hubb Community Kitchen, a group of displaced Londoners who banded together to cook for their families and neighbors in the aftermath of the 2017 Grenfell Tower fire.
Meghan's preference for eco-friendly clothing has already earned her the title of "Green Princess", so it's little surprise she is bringing the Windsors into the 21 century with an environmentally conscious fit out in her new home.