The first-leg tie will take place at the Camp Nou on 6/7 February with the second-leg to follow at the Santiago Bernabeu on the 27/28 February.
Ernesto Valverde feels Barcelona's Copa del Rey semi-final against Real Madrid will be a 'fascinating tie'.
"They were doing badly in the league but now Madrid are much better and it will be a hard tie", added Valverde, whose side have a five-point lead over nearest challengers Atletico Madrid at the top of La Liga.
His display against Sevilla, as Barcelona came from 2-0 down to win 6-3 on aggregate, was perhaps his best yet.
Real Madrid forward Karim Benzema (C) scores his team's second goal against Girona during their Copa del Rey quarter-final second leg match at the Montilivi Stadium in Girona on Thursday. Four days after that, Madrid travels to the Netherlands to face Ajax in the last 16 of the Champions League. 'We are talking about two teams with a lot of resources, with extraordinary players and we always expect very tight games.
Valverde said on Friday: 'He is a player we were originally going to sign next season but given the circumstances at his old club, we chose to finalise the deal in January, so that he can get to know his new team-mates and our style of play.
The Whites' potential opposition for this round are Valencia, Betis and Barcelona.
The final will be played at Betis' Benito Villamarin stadium in Seville on May 25.
But most importantly, winning this semi-final could reignite Real Madrid and not only can they go on to win Copa Del Rey, but with multiple El Clasico wins behind them, Los Blancos could become be a huge threat in the Champions League once again. It's thrilling and more so, if you have the fortune to play for a final.