Juve wins the match but an away goal by Atletico sees Simeone's team advance to the quarters.
Juve head into Tuesday night's last 16, second leg clash with Atletico Madrid in Turin trailing 2-0 after late goals from Jose Gimenez and Diego Godin handed the Spaniards a significant advantage.
Ronaldo was never going to miss, sending Oblak the wrong way to ensure Juve marched on at Atletico's expense, Diego Simeone's side going out of the competition after failing to record a shot on target in the second leg. Atletico Madrid are no match for Juventus when they are at their best and with the current stakes, I am expecting the Italian giants to produce their best. Only Sevilla (27) and Getafe (23) have conceded more goals than Atletico Madrid at the hands of Cristiano Ronaldo, who has torn Atletico apart in the past. It was a very hard team to play but we showed that we were a very big team.
The Portugal global forward's goals took the Bianconeri into the quarterfinals and kept him in the hunt for a sixth Champions League title - a fourth in a row - and he reflected on a "magic" night.
Ronaldo nearly scored when his long-range free kick forced Atletico goalkeeper Jan Oblak to make a hard save in the ninth minute.
Simeone has led Atletico to the final twice, and this year they could do it again.
Ronaldo had not played in Madrid since joining Juventus in a blockbuster transfer at the end of last season.
Juve went straight back on the attack after the break and quickly levelled the aggregate score at 2-2.
Juventus was runner-up in the Champions League in 2015 and 2017. It shocked the fans inside Wanda Metropolitano.