The Bucks jumped all over the Pistons early in Game 1 and never looked back from their 20-point lead at the end of the first quarter.
With Pistons All-Star forward Blake Griffin missing his second post-season game with a sore left knee, the Bucks' "Big Three" of Giannis Antetokounmpo, Eric Bledsoe and Khris Middleton combined for 77 points on 29-for-52 shooting. Antetokounmpo leads the Bucks averaging six.
They head home to Detroit for Game 3 on Saturday.
While Yahoo Sports' Vincent Goodwill reported Griffin would likely miss the entire series against the Bucks, the 30-year-old Griffin was spotted putting up shots prior to Wednesday's game.
Giannis finished 11-for-18 for 26 points, including 1-for-3 from 3-point range, to go with 12 rebounds.
Griffin wasn't officially ruled out of Wednesday's 120-99 Game 2 loss until nearly tip-off, but sit again he did after doing some work in shoot-around.
Ultimately, it came down to their performance in the third quarter, as they were outscored 35 to 17 in that quarter.
Antetokounmpo opened the second half with a layup before the Pistons took the lead again on a dunk by Drummond. Milwaukee ranks seventh in the National Basketball Association with 26 assists per game.
What do the Pistons have to lose at this point? The Pistons have played eight games this season without Griffin.