They will have more need for that kind of performance when they face Spurs and Manchester United in their next two league games.
A miss by Raheem Sterling early in the game though, just 10 minutes after kick-off in fact, provided about as much error as City would like to see for the entire afternoon from their side, as the in-form forward dragged a sitter wide after having the ball squared to him.
"That's true (it is a risky game)", said Guardiola.
Asked how we'll approach a game against a team whose Premier League fate has already been sealed, Mauricio replied: "Always with all the respect".
"Selhurst Park is always hard, not just for the stadium itself but for the quality of the players they have".
Guardiola's upbeat attitude, despite a first defeat in 15 games, suggests a longer-term plan to keep his squad as fresh as possible for a gruelling run-in.
After Palace, City host Tottenham twice in four days in the second leg of their Champions League tie and the Premier League.
Chelsea's winning streak came to an end at Anfield on Sunday as Liverpool returned to the summit of the Premier League with a 2-0 win.
Sterling showed the other side of his game, tracking back to help Walker deal with Wilfried Zaha, and Aguero fired over as City maintained their control.
"We have played with incredible personality in the last two or three months - we have taken 183 points in two seasons and still have five games left. We know what we are playing for and we are going to prepare well", added Guardiola.