Federer's only French Open title came in 2009 and his preparations have been disrupted by defeat to Thiem in Madrid and his withdrawal from his Rome quarter-final against Tsitsipas. He displays the mental toughness and calm demeanor needed to win.
The legendary Australian started the new era with 13 grand slam titles under her belt and continued to dominate.
The appointment will be at the French Open, where, as assured by Serena, she should be there.
Australia's Ashleigh Barty is a possible last-16 opponent and should she keep winning, Williams could meet world number one Osaka in the quarter-finals.
One huge shocker Mair is calling for at the French Open 2019: Williams, a three-time champion and one of the top Vegas favorites, fails to win her 24th career Grand Slam title this week. "Honestly, it's been a bit of a ride trying to figure out how to play better on clay throughout these years, but I think this year I have been playing well".
On her Wimbledon debut previous year she memorably beat world number 36 Irina-Camelia Begu to reach the second round where she lost to another Romanian, Mihaela Buzarnescu.
Osaka became the first female player since Jennifer Capriati in 2001 to win her first two grand slam titles back-to-back when she followed up her US Open triumph by winning the Australian Open in January. This is an inevitable part of the season.
Those respectable showings might not seem like much to get excited about for the world's top-ranked player, but the results are a positive sign when taking her past efforts on clay into account.
Her No. 1 ranking is also under threat as it has been for much of the spring - Bertens, Pliskova, Angelique Kerber and Petra Kvitova could all leave Paris as the world's top player.
Williams, seeded 10, has played just one clay court match this year.
Williams will go into Roland Garros seeded 10th, meaning that she will not have the luxury of an easy draw ahead of her either. Pliskova and Williams have never met on clay before, and stand dead even in their overall history. The pair have only met once on clay at the 2013 Rome Masters, a tournament that Serena won without dropping a single set.
While a victory for Osaka at Roland Garros is certainly not out of the question, it is not being predicted either. The former No 1 and the current No 1 have only met twice on court so far - with the younger player winning both times. But while victory over Stefanos Tsitsipas in Madrid secured the 32-year-old's first title on clay since the 2016 French Open, he needs to recover from defeat to Rafael Nadal in the Italian Open final.
But if anyone knows how to craft a comeback and find a win during the seemingly impossible, it is Williams. Compare that to a 65 percent rate on hard courts over that span and a clearer picture of her struggles begins to form.
If the seedings work out for the quarter-finals, then 15-time major victor Djokovic would face Germany's Alexander Zverev who has still to get past the last eight at a Slam.