A few members who were on the ship were charged according to statements from the U.S. Attorney's office.
There may be more drugs in other containers on the ship, authorities said.
Federal agents raided the MSC Gayane on Tuesday and seized the cocaine from the Swiss-owned company's ship.
"This amount of cocaine could kill millions - MILLIONS - of people", U.S. Attorney William McSwain said in a separate tweet.
The investigation is ongoing and there are not many details available regarding the seizure.
Authorities search a container along the Delaware River in Philadelphia on Tuesday.
The MSC Gayane container ship flies under the flag of Liberia.
In February, customs agents seized 1,451 kilograms at the Port of NY and New Jersey with a street value estimated at $77 million US.
In February, customs agents seized 3,200 pounds (1,451 kilograms) at the Port of NY and New Jersey with a street value estimated at $77 million. The Inquirer also reports that the bust happened after a member the Coast Guard found traces of cocaine on Durasevic's arms.
Experts say that the boom in cocaine trafficking is fueled by excess supply in Colombia, where eradication efforts have been lax in recent years.
Among them were seizures of 450 kilograms of cocaine in May, 538 kilos of cocaine in March and 50 kilos of the powerful opioid, fentanyl, in July, WPVI reported.
According to local media, the cocaine were seized late Monday. The U.S. attorney's office in Philadelphia announced the massive bust on Twitter on Tuesday afternoon.