However, for Liverpool, their first move has been postponing their pre-season friendly game against Bundesliga side Schalke that was due to take play on 6 August, as confirmed on the club's official website.
The other new boys, Aston Villa, also face a stern opening week test against last season's Champions League runners' up Tottenham on the Saturday (10 August); while Sheffield United have an arguably easier fixture away to Bournemouth on the same day.
Of course, apart from the opening weekend, we also know that Amazon Prime will be showing two rounds of games, and they are the midweek games in the first week of December, and the traditional Boxing Day programme.
The Merseyside Derby is just one of the fixtures which will be hosted on Amazon's premium subscription service.
"With Sky Sports hosting the vast majority of games, accessing its football channels will be a priority, and loyal fans will likely see an advantage in signing up to Sky on a long-term deal".
New customers will be able to join Amazon Prime for £7.99 per month, or £79 for the year. BT, who will show 52 games in 2019-20, costs £29.99 a month while Sky, who will show 128, can cost £67.50.
The season starts on Friday, Aug 9.
"This may prove the best possible value for fans who want to see all of the action without breaking the bank", she added.
City, who have won successive Premier League titles, have picked up three points in east London in the last three seasons - scoring four goals on each occasion.
Defending Champions, Manchester City will start the defence of their title at West Ham.
Liverpool will travel to Manchester United in October and then host their fierce rivals in January.
Last season's top two meet at Anfield on November 9, subject to TV confirmation, with the return at the Etihad scheduled for April 4.
Pep Guardiola's men do not face any teams who finished in the top half last season in their final six matches, following the visit of Liverpool.
The upcoming top flight season will be the first to include a brief mid-season break.