Pakistan has strongly denounced the terrorist attack in the Afghan capital, Kabul, on Monday morning that reportedly resulted in scores of casualties.
Afghan security officials said the truck loaded with explosives was detonated near the ministry's engineering and logistics department at rush hour.
Interior Ministry spokesman Nusrat Rahimi said there were two attackers, and that they had targeted the Defence Ministry's facilities.
Hours later, the Taliban claimed responsibility and said they were targeting a "technical installation" at the defence ministry.
The outbreak also runs parallel to the seventh round of peace talks, which began on Saturday between US special envoy Zalmay Khalilzad and the Taliban. In one case, on March 23, 2019, a U.S. airstrike in Kunduz killed 10 children.
Shams Amini, a spokesman for the Afghan Football Federation, told AFP that the blast occurred near their headquarters gates, and said some colleagues had been injured. Special forces cordoned off the area while intermittent gunfire was heard, Reuters quoted witnesses as saying. Among them were 50 children, the education ministry said in a statement, adding that most had been hurt by flying glass and were in stable condition.
Thirty-five school children were wounded, said Nimatullah Hamdard, the director of a nearby private school. "We were sitting inside the office when the world turned upside down on us", Zaher Usman, an employee at a branch of the culture ministry, which he said stands just 150 metres (yards) from the blast.
The latest talks between the United States and the Taliban meanwhile stretched into a third day.
The Taliban have refused to halt their violence, believing that they have the upper hand as the United States is eager to leave.
The Afghan forces put an end to coordinated Taliban attack in Kabul city by eliminating the remaining 5 assailants.
The negotiations were expected to focus on working out a timeline for the withdrawal of foreign troops from Afghanistan and on a Taliban guarantee that militants will not plot attacks from Afghan soil.
An all-Afghan peace summit has been set for July 7-8, although the talks in Qatar will apparently be held without the official participation of the Afghan government.
The Afghan government called the attacks on civilians and school children "an inhuman" and un-Islamic act.
Despite peace talks gaining momentum, fighting between the Taliban and Afghan forces who are backed by the foreign troops, has raged across Afghanistan.
"Regarding terrorism, we've made real progress and are almost ready to conclude a draft text outlining the Taliban's commitments to join fellow Afghans in ensuring Afghan soil never again becomes a safe haven for terrorists", Pompeo said.