He has been suffering from a stroke since 2015 and underwent rehabilitation two years ago.
The football fraternity would forever remember him for his enormous contribution to Ghanaian football.
Agogo played 27 times for his country and scored 12 goals - including three during the 2008 Africa Cup of Nations, where the Black Stars secured a third-placed finish.
His former clubs were among those to pay tribute on social media.
Agogo scored 12 goals in 27 worldwide caps for Ghana during the height of his career between 2006 and 2009. "Because I couldn't speak".
Agogo had a brief spell on loan with the Spireites from Sheffield Wednesday in 1999, making four appearances for the club.
Liberty Professionals wrote: "We are saddened by the news of the demise of former Black Stars forward, Junior Agogo".
A short spell at QPR followed but he moved to Barnet in 2002 where he found his form in front of goal again with 19 in 39 games.
He enjoyed the most prolific period of his career with Bristol Rovers scoring 35 times for the club before moving to Nottingham Forest in 2006, scoring 21 times.