Guptill suffered a right abdomen strain while fielding in the second T20 in Kandy on Tuesday and did not bat as the Black Caps claimed a four-wicket victory to clinch the best-of-three-match series.
Once again, the experienced pair of Southee and de Grandhomme were the stars of the show.
Choosing to bat first, Sri Lanka got off to a brisk start before opener Kusal Mendis was caught by New Zealand stand-in captain Tim Southee at mid-off off the bowling of Seth Rance for 26.
Shehan Jayasuriya remains down after colliding.
It evoked memories of New Zealand's test against India in Bangalore in 1988 when Sir Richard Hadlee snared his world record 374th test wicket then half the team were struck down by illness, meaning television reporter Ken Nicholson and former skipper turned radio commentator Jeremy Coney were summoned to field.
The 30-year-old left-handed opening batsman has been playing County Cricket for English side Worcestershire, having scored 317 runs in the domestic 50 over competition.
They had their struggles, going five overs without a boundary, and wicketkeeper Kusal Perera was kept busy by an array of inside edges when mistiming slower balls.
Taylor, meanwhile, has been ruled fit and ready to go, after being left out of today's match as a precautionary measure.
New batsman Daryl Mitchell hit a ball straight back to the bowler Hasaranga, who flung it quickly to the wicket at the non-striker's end where Bruce was found short of his crease.
He promptly delivered - with a little help from one of cricket's strangest incidents.