The commercial climaxes with the former San Fra saying, "Believe in something even if it means sacrificing everything".
It beat out impressive ads for Netflix as well as Apple's Macbook, iPhone XS and Sandy Hook Promise. Kaepernick was one of the faces of Nike's 30th anniversary commemoration of its iconic "Just Do It" campaign.
The business is a tribute those that dream "dream insane", a message which matches alongside Nike's long-standing "just do it" slogan. "Ask if they're insane enough".
Kaepernick was at the center of the "Dream Crazy" commercial which featured other star athletes such as LeBron James, Serena Williams, and Shaquem Griffin, illustrating how athletes have pushed boundaries to be the best at what they do, Deadline reports.
The league issued a statement on the commercial previous year.
"There was speculation that the Nike/Kaepernick campaign would lead to a drop in sales but the data does not support that theory", the company said in a statement.
Since leaving the NFL, Kaepernick has devoted himself to social justice activism. It featured the former National Football League quarterback and the slogan: "Believe in something". In July, the company walked back its decision to release a red, white and blue "Betsy Ross" edition of its Air Max 1 sneakers, reportedly following concerns raised by Kaepernick about glorifying the era of slavery.