Ricksen told television show De Wereld Draait Door in 2013 that he had been diagnosed with the disease just a few months after retiring from the professional game.
Former Netherlands and Rangers player Fernando Ricksen has died at the age of 43 following a battle with motor neurone disease, the Scottish Premiership club announced today.
Ricksen begun his career with Fortuna Sittard in his native Netherlands before moving to AZ Alkmaar in 1997.
Peter Lovenkrands, who also joined Rangers in 2000 and spent six years with the club, paid tribute to his former teammate on social media.
It will be an emotional encounter in Glasgow after the news of the death of Fernando Ricksen on Wednesday, with everyone involved with the Gers wanting to win as a mark of respect for their former right-back.
It attracted more than 41,000 fans to Ibrox, raising £320,000 ($399,000) with the proceeds split between Fernando, his daughter Isabella, MND Scotland and the Rangers Charity Foundation. You'll be truly missed. He left Ibrox for Russian side Zenit St Petersburg and was there reunited with Advocaat.
Fortuna, now second bottom in Eredivisie, and Zenit, second in the Russian top flight, both paid tribute on Twitter.
"He battled bravely against motor neurone disease right until the end and we are all thinking of him and his family at this hard time".
He was part of the Zenit squad that faced Rangers in the 2008 Uefa Cup final, which the Russian side won 2-0.