In the absence of the formidable attacking trio of Kylian Mbappe, Neymar and Edinson Cavani, Di Maria provided two first-half goals as PSG suffocated Real throughout and Thomas Meunier added a third in stoppage time.
Zinedine Zidane fumed at Real Madrid's lack of intensity after the 13-times European champions started their Champions League campaign with a chastening 3-0 defeat to Paris Saint Germain. The French fullback will start in place of the injured Marcelo and the pressure will be on as Los Blancos kickoff its Champions League campaign in Paris.
However, the Spanish giants were outplayed by PSG, despite the French champions missing Neymar, Mbappe and Edinson Cavani.
Former Real Madrid goalkeeper Keylor Navas, who joined PSG late in the summer transfer window, should get the nod on Wednesday night.
Captain Thiago Silva and Abdou Diallo are expected to feature as the two centre-backs, with Presnel Kimpembe featuring for just 20 minutes after returning from his injury layoff last weekend while Marquinhos could slot in as the defensive midfielder for the hosts as he had done earlier this season. Since Jesus Vallejo is on loan, Zidane does not have many choices for his two center backs.
There is no looking past Thibaut Courtois in goal, meaning former PSG No. 1 Alphonse Areola has to make do with an appearance on the bench.
Luka Modric, Isco and Marco Asensio are also injured, while Nacho and Sergio Ramos are suspended.
"In the play, in midfield, and the thing that annoys me most is the intensity".
Zinedine Zidane had a strong team out, with Eden Hazard, Gareth Bale, James Rodriguez and Karim Benzema all starting for Real Madrid.
PSG, who kick off their Group A games against Real Madrid on Tuesday, appealed against Neymar's ban after he took to social media to criticize the officials following their Round of 16 second leg defeat to Manchester United last March.
It was a match where Real Madrid could do very little in attack.
'They're good at creating chances, that's not what worries me.