In an interview with Additional on the set of the Fox drama, Howard informed correspondent and present Miss USA Cheslie Kryst that he's "finished with appearing" after "Empire" wraps manufacturing.
Howard, 50, did not share why he made a decision to quit and did not elaborate on what career he plans to pursue instead.
Looks like Terrence Howard is ready to retire from the acting game. Meanwhile, Howard has a lengthy list of hit films under his belt, including The Best Man, Big Momma's House, The Butler, Hustle & Flow.
Fox will air the sixth and closing season of "Empire" on September 24.
Asked his plans after "Empire", he told "Extra": "I'm done with acting".
When Howard was pressed by Kryst to give details and if he'd go off into philanthropy, Howard came off cryptically.
When Kryst followed up, asking if he is, instead, choosing to focus on "philanthropy and other interests", he clarified, "No, not philanthropy; I'm just focusing on bringing truth to the world".
Howard did not elaborate on what he meant by delivering the "truth".
Jussie Smollett beforehand starred in the Fox drama.
Of claiming goodbye to Empire, he added: "I cherish the solid contributors".
The Blast obtained court documents that state the U.S. Attorney's Office is probing into possible financial crimes involving Howard, his third wife Mira Pak and Universal Bridges Inc. which is owned by Pak.