Kwadwo Asamoah came up against his former club, Juventus, at the San Siro on Sunday, but ended up on the losing side of a 2-1 defeat, which ruined the Nerazzurri's 100% start to the 2019-20 Serie A season.
A thigh downside meant Lukaku missed Inter's Champions League defeat to Barcelona final Wednesday and Antonio Conte had no hesitation placing the 26-year-old straight again into his beginning XI this weekend.
Paulo Dybala's opener was cancelled out by a Lautaro Martinez penalty before Higuain's late decider.
"We should not forget that Juventus have been on this course for a long time", said Conte, who led the Bianconeri to the first three of their eight successive titles.
It was the Nerazzurri's first league loss of the season and took Juventus back above them in the table by one point going into the worldwide break. "We have won six games bringing the vehicle to 200 miles per hour and we will try to do it again".
Matthijs de Ligt gave away the penalty for Inter's equaliser in the top-of-the-table showdown - the young Juve defender blocking Nicolo Barella's cross with a raised arm.
The Belgian has scored three targets since his £74million transfer from Manchester United and may have been determined so as to add to his tally towards Juve, however Gonzalo Higuain stole the headlines with a late victor for the Serie A champions.
He added: "From this point of view, we have already taken important steps".
The home side lost Stefano Sensi to injury after 33 minutes and to make matters worse, it looked like Juve had gone ahead for the second time just before the break before Ronaldo's strike was ruled offside.
Atalanta have 16 points in third after their impressive start continued with a 3-1 home victory over Lecce.
"We said a lot of wrong things during the transfer window, but I stayed here, that's what I wanted".
Roma are fifth, a point behind Napoli, with their match against Cagliari at the Stadio Olimpico finishing 1-1 after Nikola Kalinic's last-gasp goal for the hosts was disallowed.
Lazio's Joaquin Correa missed a chance for the victor when he sent a penalty kick over the bar two minutes from time.