'I have to say that not replacing Vincent Kompany now, and obviously the injury to Aymeric Laporte, is a big problem for them because they look vulnerable.
Let us know in the comments. It was a very good performance - but more than the performance was the work the players did.
According to Mirror report, the De Bruyne suffered the groin injury in the closing moments of last weekend's win at Everton, meaning the playmaker played no role for the Citizens during midweek's UCL win over Dinamo Zagreb.
Wolves were unlucky in the first half not to have leapt into the lead.
Guardiola defended his players, however, and believes there is plenty of time left in the campaign for them to claw their way back into contention for a third consecutive Premier League triumph.
It was City's second defeat in their last four league games following the 3-2 loss at Norwich City last month and it will increase Liverpool's belief that they can win their first league title in 30 years.
Manchester City head into the global break eight points behind leaders Liverpool following a shock loss to Wolverhampton Wanderers on home soil.
Wolves were the fourth English side to play away at Besiktas since the Uefa Cup was rebranded and the previous three - Stoke, Spurs and Liverpool - were all beaten.
The second half saw a change as Oleks Zinchenko came on for Walker and Cancelo went to the right back slot.
But Nuno Espirito Santo's outfit put in a spirited display at the Etihad to frustrate Pep Guardiola's side.
Wolves were slipping deeper and deeper and a City goal looked inevitable but Wolves hit them with a flawless counter-attack with 10 minutes remaining to send shockwaves around the Premier League.
That victory game against Watford whom they defeated 2-1 back in April.
Manchester City have now lost twice in their opening eight league games and go into the worldwide break eight points behind Liverpool.