Spurs continue to struggle in the league and Mauricio Pochettino will know that another emphatic result in Europe could provide the spark to reignite their season.
On paper, a meeting with Group B's underdogs tonight appears the ideal tonic for last season's Champions League finalists, particularly given their five-star demolition job on the Serbian outfit two weeks ago.
Red Star almost leveled in similar circumstances shortly after when Rajiv van la Parra's shot smacked against the post and Tottenham defender Davinson Sánchez hit his own crossbar with a botched clearance.
"Red Star will not be fooled by what they have to do, but they will have been embarrassed by what they went through in London".
In this fixture last time out Marko Marin was Red Star's danger man, carving out no fewer than six chances for his teammates.
Leading the line, Spurs have two of the most electrifying forwards in European football in Harry Kane and Heung-min Son while the creative talents of Christian Eriksen, Lucas Moura and big-money signings Tanguy Ndombele and Giovani Lo Celso are world renowned.
"Sonny was devastated after Sunday, but he is on good form now".
Kane has been a revelation for Spurs in the Champions League, scoring 18 goals in just 22 appearances since making his debut against Monaco in 2016.
Tottenham move four points clear of Red Star in second place in Group B and will guarantee qualification with victory at home to Olympiakos on November 26.
"This season, after the Champions League final and he played with the national team in the middle of June, he had surgery in his groin and of course the pre-season wasn't the best pre-season for him". With nine points from their first three games - and a almost unblemished record of 10 goals scored and just one conceded - Pep Guardiola's side is marching toward and early progression to the round of 16.
Home and away wins over Red Star are Tottenham's only wins from its last seven games in all competitions.
Harry Kane missed the defeat to Everton due to a virus but the club captain, who has scored 10 goals in all competitions this season, is set to return to the starting line-up in Belgrade.